As the consensus on Spacebattles is that on the ground, Crysis is one of the most deadly sci-fi settings around (they even came to the consensus that the Ceph would massacre the Covenant on the ground) I decided to place one of the deadliest sci-fi power armor users ever against the events of the series as a whole. Going from fighting the DPRK on Lingshan to battling the Ceph assault ship in the heart of New York. Given that Samus is quite a ways beyond Prophet, Alcatraz, and Nomad; in this scenario she won't have support, but she'll have the combined arsenals of each of her game. If she still heinously outmatches CELL, the DPRK, and the Ceph, then enemy numbers are doubled.
For Samus to win, she has to effectively beat the events of the entire series. For the Crysis side to win, they merely need to put her down. Let's assume the enemies will drop standard metroid pick-ups, but other than that she gets no added advantages.
Round 2: For added funsies, the Protagonists of each Crysis game will also be deployed against her.
By act of ROB Samus is made immune to the Ceph virus.