Sam and Dean vs Stefan and Damon.

I know I'm probably going to get carp for this, and these aren't really comic book Characters. but who would win in this encounter?
Sam and Dean are on a case of body's drained of blood but they are different then the vampires they're used to.
The brothers then figure out they are a different form of vampire. The Winchester's have all their gear, and the Salvatore's are at full strength. Who would win? And how would it go?

Damon solos. As a team, Salvatore stomps, hard.

it depends...in a random enconter, the salvatore would win 10/10

but if the winchesters know who they will fight, than they can preper, and take them down! they have beat the werewolves, vampires, shappshifters, witches, wizards, leviathans, demons, angels, archangels, and the Devil Himself! they have put both Michael and Lúcifer in the cage...there's nothing they can't do!...and theres's of course, the fact that they can't die, and be dead...GOD will eventually bring them back...that was explained by Ash on season 4 episode 16...Dean and Sam have been dead countless times...but they never stay dead, GOD always brings them back...so if the salvatores kill the winchesters, GOD will bring them back, over, and over again, until they get the job done! and if they can't, tahn GOD just erases the salvatores from existance, in order to Dean and Sam to continue thei're journey...xD

With no prep. Sam and Dean lose.

@wasmiley Both the Salvatore and Winchester brothers have appeared in comic books.

Salvatore borthers

Either one of them solos far too easily. They could, literally, force the duo to slap each other to death.

However, it might change with prep, prior knowledge, and allowing resources cross-universe. But yeah, literally, God will have to interfere for sam-dean to pull off a win. Either way, that's still a loss for the thread.

Bump....

I dont think the Winchesters can handle the Speed Blitz from either of the salvatores.

Sam and dean with prep