Random encounter in the desert. No morals, 45 feet away. Rogue has Ms. Marvel powers.
I remember this Hulk losing to Spider-Man once, I don't remember where exactly. Rogue wins.
That was Spider-man with Captain Universe powers. he punched Hulk into orbit. Hulk was floating around, thinking about how he could hold his breath a while, but not forever. Captain Universe would own most characters, lol.
I think Rogue due to versatility, speed, ability to take a hit, and her absorbing powers. Its just too much altogether for Hulk.