All have become immortal and have 1000 years of prep. No outside help. No attacking someone before the 1000 year finishes. No HOTU, IG, ALE.
Of those one's I'm actually going to say Lex Luthor. He's the smartest human in DC (And I maintain the smartest human in either company), and he prepped to overcome his own death (the whole clone thing). He also became a god at one point, and despite being one of the great villains he also successfully ran and won the Presidency.
Though I stil think The Doctor (Doctor Who) is the prep god.