Nice choices.
Run down of the combatants,
Super Strength: Both are incredibly super strong but I think that i might give the edge to Orion.
Durability/Regeneration: I think that Orion is the harder to hurt (and thus KO) but that Lobo's regeration power is greater.
Endurance: Both have massive amounts of energy reserves so I don't see an issue with them tiring.
Agility/Reaction Time: Although Lobo is way faster than a normal human, I would give Orion the edge here again.
Fighting Ability: Both are massively experienced but I think that Orion might be more formally trained i.e. Martial Arts.
Others: Well Lobo has his Flying 'Hog' so he can get around fast but Orion has the Astro Harness (enables projection of the Astro force - a hugely powerful enegy weapon) and he has Mother Box - for aid, advice , travel vis Boom Tube etc.
Orion is meant to be able to beat Darkseid (eventually in combat).
With all this in mind, I would actually go for Orion to win (via KO possibly) but Lobo would after he recovers just keep getting up.
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