Macguyver has 1 hour prep in a weapons factory that is funded by Stark Enterprises. Security sounds off and Black WIdow is the first to respond. Unfortunately for him, Macguyver has 1 hour prep to cook up something devious.
Macguyver would probably win.
The whole show is him getting into trouble every episode and then PISing his way out of that. (Kind of like I understand The Doctor work, though I don't watch it)
I'd say he's similar to JonCon in that regard. They both excel at short term prep.