Lizard (Amazing Spider-Man)
Whiplash (Iron Man 2)
Start 100 yards apart in the middle of a busy Manhattan street. Bystanders and cars are all around the place, but nobody will directly interfere with the fight (no SWAT or cops.)
This is Whiplash at the beginning of the movie, where he only has the whips, not the big armored suit.
Win by incapacitation or death.