You're going to have to specify what in character actually means for Leon. Do you mean the popular version from RE4 that is actually the result of the translator throwing the original script in the trash and doing his own? Or the RE6 version which while "canon" is far far worse?
Leon takes this if RE4 version, loses if RE6. He'll QTE out of the way of any attack Hood throws, pop his head with a suplex and then make a quip before going back to saving the president's daughter from terrorists.