Deadpool and Deathstroke will probably be debated for ages - While I do think Deathstroke would win, it would be a very hard earned victory and would definitely leave Deathstroke with grievous injuries. Deadpool's healing factor is a lot better then Slade's - While Slade has been shot in the head and has taken Anti-Tank rounds the body, that's nothing that Deadpool couldn't also get up from more quickly then Deathstroke. Wade has been shot by a Rocket launcher point blank to the chest and didn't show any signs of injury, jumped out of a plane thousands of feet in there and landed on his head, only to get back up and joke about it. Slade was stabbed through his heart and other internal organs and kept fighting even while not at 100%. Wade has been stabbed in the brain by Wolverine, which barely phased him. Bullets have harmed him in the past, but not to the point where he's been brought down entirely from them. Deathstroke is packing some heat - Guns, a Blast Staff, a Sword, whatever is in his usual arsenal, but none of those things are a surefire way to take Wade out of the fight early. Deadpool cannot die - and it takes a heck of a lot to even slow him down. Deadpool can tank a lot of what Slade brings to the table - Their enhanced durability would make this fight last quite a while.
Let's talk about skill: Deathstroke has smacked the Justice League and the Teen Titans like they were amateurs, he's brought down the Batman quite handily and Nightwing isn't even a viable threat to him - He's stated to have been trained in Military Combat as well as extensive martial combat training from his wife. He can hang with the best of them, no doubt about that - but then again, So can Wade in his Universe. He's surprised Cap in combat twice, he's given Logan some decent fights over the years, despite Wolverine's surpassed skill level (Which is a lot higher than Slade's, IMO), he's fought whole teams of Superhumans like Slade has as well - the Brotherhood of Evil Mutants, the X Men, and a team of Anti-Registration Avengers. None of those fights ended quickly, as Deadpool was able to keep up with all of them (Albeit briefly). and even in the Brotherhood of evil Mutants fight, Wade wasn't sporting a healing factor at the time and was still able to perform exceptionally against them. Wade is sporting something that Deathstroke doesn't have in this fight - his insanity. Deadpool fights like the Joker except way better trained and has way better physicals - he will do anything to get a win even if it involves getting grievously injured himself. Odds are, Deathstroke is going to have a bit of trouble if Wade decides to drop some grenades at their feet during the fight.
Physicality-wise, I'd give the edge to Deathstroke, but it's not by a huge gap. Wade's endurance is off the charts, and his agility/speed are clearly superhuman as well. I'd actually say that Wade might have the edge in speed and agility, but they're very close. Street levelers like Nightwing, Batman, heck even Tim Drake have tagged Slade, so it isn't like his reflexes are that much beyond peak human. The Flash tagging feats are all circumstancial - A no holds barred Flash could beat Deathstroke with ease on any given day. Same thing goes for him beating Green Lanterns - I don't care how much Slade has "studied" them, guys that can take on Planetary threats would not be so easily beaten by a simply enhanced soldier with good fighting skills. Sorry if I'm nitpicking here, but w.e. - Bottom line, Deadpool and Deathstroke have comparable feats in terms of all physical aspects, except for maybe Strength, but again, if Wade can cut down a tree with a karate chop and knock a guy's head into a brick wall with a kick, Slade's going to feel Wade's blows.
Sorry for the length, but I just want to make it clear that Slade isn't that much higher then Wade is in terms of a lot of things. It angers me when people lowball Deadpool and write him off as some joke based on a small handful of showings. Honestly, Wade would give Deathstroke all hell if he's intent on killing him, and perhaps only Slade's higher brain capacity would save him in the end. I'm giving this to Deathstroke, 6/10. I personally think Wade has the skill and the insanity to pull off a few wins.
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