Dante and Neo in the Matrix.
Dante and Neo have there full strength and abilities (weapons to).
Neo's powers and abilities http://en.wikipedia.org/wiki/Neo_(The_Matrix)#Powers_and_abilities
Dante's powers and abilities http://devilmaycry.wikia.com/wiki/Dante#Equipment.2C_Powers.2C_.26_Abilities
who's going to win?
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