The only way to kill Alex is to fully consume him (which James didn't do, he tore his arms off and threw them to the side, and didn't consume them, meaning Alex could come back and is still alive), he took a nuke and instantly came back. Cole would disintegrate. Their resistance to damage is also much higher than Cole's.
They both also have a HUGE intelligence advantage over Cole (they gain the knowledge of everybody they consume, which was a lot of people, including scientists), so that gives them a big advantage when it comes to gameplanning and what-not.
As for strength, that easily goes to Mercer and Heller. At the beginning of Prototype 2, Alex effortlessly picks up a tank with one arm and flings it like a frisbee. That gives them an advantage in punching and kicking power in close range combat (one hit will likely kill or seriously injure Cole, especially with Alex's muscle mass power-up), and they can also use projectiles.
The devastator attacks would put an end to Cole very quickly. Of course, they can shapeshift their body into weapons, and can pick up weapons from soldiers and use them.
Really, I don't see how Cole could beat either of them.
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