Movie Blade, with standard equipment. No prep time. Fight takes place in an empty warehouse.
Side note, I have not been following American Vampire for some time, but I seem to remember that Skinner and Pearl's species could only be harmed by gold.
Yeah and I think theirs an issue with the moon also that was touched upon in the recent Travis arc. Skinner was at his weakest because of the moon.
Movie Blade could hang with Skinner but he cant put him out with standard gear, because of a lack of gold