Nick Fury captures 5 people who genetically alter their DNA. He takes Doctor Otto Octavius, Kraven The Hunter, The Sandman, Electro, and Norman Osborn. He puts them in a S.H.I.E.L.D headquarters where they have session with Hank Pym. Fury finds it a precaution to take them without them having any rights so that they can reverse their altered DNA so they can have a proper trail, while also doing so governmental stuff. Fury believes that the next war will be a genetics war and that by taking these 5 it will be one step closer for them to solve a problem before it starts. But, everything goes wrong when Octavius decided to help. He claimed that without his arms he is nothing and that before he dies he wants to do some good.
Fury talks to the Ultimates. A team that is headed by Fury and he asks them to decide weather or not Otto should help. He tells them he asked first because if something goes wrong they will have to be the ones to go and stop him. Captain America gets angry and never make a decision and wonders why Nick had continued with his experiments on trying to create the serum that turned Steve Rogers into Captain America: The First Successful Super-Soldier in the first place. But Otto is let out and is near his arms. He is talking saying that he can hear his arms and that it could be a connection. The arms by itself goes through the bodies of the four people he was with and he ends up bailing out the others and takes information from S.H.I.E.L.D.'s computer base.
Since Nick had 38 agents at the site and only 3 of them survived, Nick thought of the only person who they all have in common and knowing that the only person that has battled all of them before Nick Fury went to get Spider-man. A government agent picks Peter up from school and tells that the people he fought has escaped. Aunt May and MJ are being watched by S.H.I.E.L.D and have agents making sure their okay. Meanwhile, Norman calls the Secretary of the White House calling him his old friend since they went to school together and has made demands. The President calls Fury into the White House and tells him that if the problem won't be fix he will arrest Fury for treason. With the Ultimate Six having S.H.I.E.L.D information they was able to break in and they ended up grabbing Peter without his mask on. Norman had told Peter that he had no other choice but to join him and the others or his Aunt May would die.
He goes with them to the White House where the final battle would be. It ends with Harry trying to talk to his dad and telling him to stop what he is doing. Tony attacks Norman and they take Norman away so that they can get his DNA information. Harry says to Peter he will kill them all. Peter ends up back at S.H.I.E.L.D, with Aunt May thinking that he was in another facility and will be brought home. While locked up Kraven and some of the other decided to say that they were under mind control by Doc Ock and Norman.
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