Fantastic Four's enemies

Former Herald of Galactus. His best friend is Firelord

Apocalypse is one of the most powerful mutants in the Marvel universe, possessing a multitude of superhuman abilities, including almost unsurpassed strength, invulnerability and the ability to both shift and alter his mass and form.

Blastaar is a Balurrian from the Negative Zone.

A former SHIELD agent sent undercover. Constrictor soon became what he was trying to stop.

Devos the Devastator's sole responsibility is to eliminate every life form that has any prospect of ever waging war.

The four heroes that make up the Fantastic Four are Thing, Mr. Fantastic, Human Torch, and the Invisible Woman. The Fantastic Four gained the powers after exposure to cosmic rays while they were a scientific exploration mission in outer space. Reed Richards was a scientific genius who now has the ability to stretch and bend his body into incredible lengths and shapes, he is called Mr. Fantastic. Ben Grimm was turned into a being with immense strength and a rocky appearance, he is now called Thing. Johnny Storm gained the power to cover himself in flame and fly, he is known as Human Torch. Sue Storm now has the ability to become invisible and create forcefields around herself as well as manipulate them around other objects. Collectively this group is known as The Fantastic Four. They are enemy to many and have saved the Earth countless times. Doom is a highly intelligent man in the sciences and in mystical areas. He has the ability to exchange his mind with others. He has created several technological inventions including robotics (particularly with the development and advancement of his Doombots) and even a time machine. His suit of armor gives Doom super strength, flight, and the ability to create concussive blasts. Doom has made several modifications over the years.

Dragon Man is a synthetic lifeform created at Empire State University by Professor Gilbert. Unable to grant it life by himself, the villain Diablo animated him with his alchemy. He has battled the F4.

Elspeth Cromwell is a world renowned exorcist with great magigal abilities. She comes into conflict with Reed and Sue Richards and accidently summon Mephisto.

Galactus is the famed "devourer of planets" in the Marvel Universe. His powers are nearly omnipotent. He has appointed a number of entities as his heralds, imbuing them with the Power Cosmic.

Led the street gang called the Bacchae in infiltrating the Fantastic Four Headquarters.

The son of Franklin Richards and Rachel Summers, Hyperstorm has powers many times magnified.

A Poppupian from Poppup. He is not really a villain, he just want to have fun.

Klaw has a gun on his arm that turns sound into images. Recently, his body was converted into pure sound.

Kurrgo, the master of Planet X, and would-be emperor of his miniaturised people!

The evil doppleganger of Adam Warlock, Magus believes Good and Evil are tools to chain sentient beings. His goal is to give all lifeforms a purpose: To Worship him or Die.

M'Baku is a worshipper of the sacred White Gorilla who was exiled from Wakanda because of his actions in leading the cult. A sacred ritual gave him apelike strength, agility and stamina.

The Fantastic Four, like the Avengers, are a recurring Mephisto enemy. He once captured two of the members' souls, and they thwarted his attempt to take their souls many other times, along with other innocent people.

It was his goal to carry on the prophesy of the Eternals. "From Beyond the Stars Shall Come the Overmind - And He Shall Crush the Universe!" He was stopped by the Fantastic Four.

Ruler of Hades, the Underworld. God of the Dead.

Stepfather to Alicia Masters, the Thing's off and on girlfriend. Puppet Man is also one of the Fantastic Four's oldest enemies.