Cyclops and Wolverine rescue a mutant (Ugly John) from a Sentile. Ms. Nova shows Donald Trask how homo sapiens slaughtered the neandertals thirty thousand years ago and then tells him that mutants will do the same to humans within a few generations. Xavier is trying out the new cerebra when a large spike of the mutant genes is spotted in South America. He asks Cyclops and Wolverine to investigate. Xavier hears a voice inside his head that tries to take control of him, but is saved by Jean. Ms. Nova takes Mr. Trask to a Master Mold facility in South America and introduces him to Wild Sentinels.

Beast and Jean find Emma Frost amidst the death and destruction in Genosha. She seems unhurt and she’s developed a diamond hard outer layer of skin. The X-Men wonder what to do with their prisoner Cassandra Nova, the woman behind the Genoshan carnage. They learn that Cassandra’s a new kind of living being on Earth and she wants to destroy mutantkind so her species can dominate. Soon humanity will die out, leaving only mutants and people like her in existence. Cassandra attacks the X-Men and tries to use Cerebra to wreak havoc. Professor Xavier shoots Cassandra and Emma helps the X-Men during the melee, changing her mind after deciding to leave them earlier. Taking a rest, Cyclops and Jean try to resolve personal and marriage issues while Professor Xavier comes out of the closet to the whole world. On television he announces that he is a mutant.