Doctor Octopus appears in 1376 issues.
A former nuclear physicist and atomic researcher, Dr. Otto Octavius's life changed forever when one of his experiments went horribly wrong. From that day forward, he has set out to prove his superior intellect in a number of ways, but these plans are usually thwarted by Spider-Man. Doctor Octopus, in order to remain alive, swapped his mind with the mind of Peter Parker (Spider-Man). By doing so, he saw Peter's memory. Now understanding why Peter is a hero, Doctor Octopus vowed to be a Superior Spider-Man.