Younger sister of Destiny, older sister to Dream, Destruction, Desire, Despair and Delirium. It is said that everything living thing encounters death twice in their lifetime. Once when they are born, though no one remembers that meeting with her, and once when they die. Death does not guide the soul of the dead into any particular afterlife, she is merely a gateway into what lies beyond. On page she usually appears as a young woman, stylishly dressed wearing a silver ankh, with pale skin, and an eye of Horus tattoo around her eye. Though like the rest of the Endless, she can appear however she wants or needs.

When the universe was young Death was more somber, but she has come to love her job and develop her own quirky upbeat personality beyond what the fear living beings have of her. It is known that she keeps two goldfish and has a floppy hat collection. She is Dream's closest friend and confidant, able to shake him out of self-absorption when necessary. She does not seem to have much of relationship with either her elder brother Destiny, nor her younger siblings.

Twice Death has agreed not to take people (on panel). In one instance it was her nephew, Orpheus, so that he could descend into Hades and bring back his love Eurydice. After being torn apart by the Bacchanae, Orpheus survived for thousand of years as just a head until released (killed) by his father Dream. The second time in Medieval England, after listening to a man claim that Death was "a mug's game", she agreed not to take Robert Gadling while Dream agreed to meet him every hundred years for a drink, just to see how long he would want to live. After Dream (Morpheus) died, she met with Gadling herself and offered to take him, but he refused.

One day in every century, Death lives a day in mortal form, sometimes human, sometimes not, to better understand the creatures over which she has dominion.

"I'm not merciful or blessed. I'm just me. I've got a job to do and I do it....When the first living thing existed, I was there. Waiting. When the last living thing dies, my job will be finished. I'll put the chairs on the tables, turn out the lights and lock the universe behind me when I leave."