So let's pretend for a moment that Deadpool won't be back in a year because Joe Quesada loves Deadpool more then he hates marriage, and shoot the shit on how Deadpool could believably die.
Seeing as how this seems to be going down around the time Venom is taking over the world, I'd like to think Anti-venom would be involved. He comes across Deadpool slicing up symbiotes with his future spear (Can't believe everyone forgot about that) when Anti-Venom 'cures' his cancer, which we all know for Deadpool is a bad thing.
SO what do you think is a way Deady could die? Also please don't answer "He won't" or "he'll be back in a year" let's at least TRY to believe he'll stay die okay?