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For unknown reasons, B.R.A.I.N is teamed up with the Mad Squad - but they are just glad it is on their side. It was created by Bavarian scientists with the single purpose to be used as a tool to rule the world. By the time the Mad Squad found the secret cult responsible for its creation, it had already mashed them up and eaten everything but their teeth and toenails.
All the Mad Squad knows about B.R.A.I.N is that it likes 1950s Hollywood melodramas, dixieland jazz and the occasional romp with heavy machinery. They do not know what it is and have no desire to ask.
As evident from the issue where it was introduced, it has the ability to survive under water and ferociously fight.