With all the death and destruction of the Annihilation Wave, it is nice to see so many characters had time to smile.
Some of them had devoted full panels for their gesture of cheer. In fact, just within the six main books of Annihilation, we see 6 (six) full panel smiles (from four different characters - Ravenous (3); Thanos (1); Drax (1); Ronan (1)):
When it comes to panels where the main focus is all about the smiles, I counted 18 (eighteen) different smile occurrences in the six main books of Annihilation:
Thanos wins the smile prize this time... and why wouldn't he? After all, he ended up with the love of his "life"...