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Amy and her family were in the group of survivors being lead by Cindy. Amy's husband, Joel, had the crazy idea that the Crossed could be stopped by using salt.
When the group was attacked by them, Amy broke his ankle and tried to give her daughter to Joel. But he was so convinced that salt could stop the Crossed, that he draw a circle of salt around his family. Obviously, Joel was unbelievable wrong, and the Crossed brutally murdered Arwen, raped Amy, and also raped her husband.
Although the family are all presumably killed in the first issue, we encounter them again through the story arc via flashbacks.